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2920 Taubman Health Center
1500 E. Medical Center Drive
Ann Arbor, MI 48109-5331

APPOINTMENTS 734.936.5738
14700 East Old US 12
Chelsea, MI 48118-1103

APPOINTMENTS 734.475.4478
19900 Haggerty Road, Suite 100
Livonia, MI 48152-1054

APPOINTMENTS 734.936.8396
8001 Challis Road, Box 0762
Brighton, MI 48116-5738

APPOINTMENTS 734.936.8396
Constance Mobley, M.D., Ph.D.

biography

Undergraduate: University of Memphis

Graduate: Vanderbilt Univesity

Medical School: Vanderbilt University

Academic Development: Transplant Immunology

Ph.D.: Dr. Mobley studied molecular mechanisms of gene transcription using the Rous sarcoma retrovirus as a model system to identify markers for transformation in eukaryotic cells. Specifically, she identified two key proteins involved in regulating basal cell transcription that contribute to the transformation potential of the Rous sarcoma viral genome.

During Dr. Mobley's research she studied the role of MMP's in rejection using a mouse cardiac allograft model system for acute rejection. She examined the expression patterns of MMP's in primed T cells and correlated the movement of T cells with the expression of MMP's and the onset of acute rejection. Dr. Mobley also studied the role of MIG chemokine in a cardiac mouse model of chronic rejection. Mentor: Robert Fairchild, Ph.D.. Institutions: Cleveland Clinic Foundation, Cleveland, OH.