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Constance Mobley, M.D., Ph.D.
Undergraduate: University of Memphis Graduate: Vanderbilt Univesity Medical School: Vanderbilt University Academic Development: Transplant Immunology Ph.D.: Dr. Mobley studied molecular mechanisms of gene transcription using the Rous sarcoma retrovirus as a model system to identify markers for transformation in eukaryotic cells. Specifically, she identified two key proteins involved in regulating basal cell transcription that contribute to the transformation potential of the Rous sarcoma viral genome. During Dr. Mobley's research she studied the role of MMP's in rejection using a mouse cardiac allograft model system for acute rejection. She examined the expression patterns of MMP's in primed T cells and correlated the movement of T cells with the expression of MMP's and the onset of acute rejection. Dr. Mobley also studied the role of MIG chemokine in a cardiac mouse model of chronic rejection. Mentor: Robert Fairchild, Ph.D.. Institutions: Cleveland Clinic Foundation, Cleveland, OH. |